Neuron-specific transcriptomic dysregulation in methotrexate-induced cognitive impairment revealed by SnRNA-seq
This study highlights the specific effects of MTX chemotherapy on hippocampal cellular function and provides valuable insights into the molecular mechanisms underlying cognitive deficits and potential therapeutic targets.
Authors
- Yifan Jia (ORCID: https://orcid.org/0000-0002-3601-9817)
- Huang Ding
- Jianhua Ren (ORCID: https://orcid.org/0000-0003-1109-8843)
- Zhongyuan Xia (ORCID: https://orcid.org/0000-0002-5807-9554)
- Jishi Ye (ORCID: https://orcid.org/0000-0003-0912-5267)
- Ruolan Wu (ORCID: https://orcid.org/0000-0002-0885-3468)
- Jingli Chen (ORCID: https://orcid.org/0000-0003-0021-081X)
- Shuang Xie
- Yu Ding (ORCID: https://orcid.org/0000-0003-2573-9584)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Central Hospital of Wuhan (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1097/js9.0000000000003519
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00