Pharmacogenomic biomarkers of ACE inhibitor–induced cough in a multi-ethnic UAE cohort
Our data showed a significant association between ACEI-induced cough and the ACE rs1799752 I/D genotype, as well as lower ACE plasma levels in the cough group. This is the first study in the UAE and Middle East to report such findings and include all these variants in a single analysis. Although the sample size is small, our results contribute cumulative evidence on the genetic predisposition to ACEI-induced cough among hypertensive patients.
Authors
- Zeina N. Al-Mahayri (ORCID: https://orcid.org/0000-0002-4673-6692)
- Mais N. Alqasrawi
- Sahar M. Altoum (ORCID: https://orcid.org/0000-0002-7944-9905)
- Dana Hamza
- Bassam R. Ali (ORCID: https://orcid.org/0000-0003-1306-6618)
- Lubna Q. Khasawneh (ORCID: https://orcid.org/0000-0001-6090-5969)
- Lilas Dabaghie
Institutions
- Al Ain University (AE)
- United Arab Emirates University (AE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fphar.2025.1655617
- Primary Topic
- Respiratory and Cough-Related Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Higher Education and Scientific Research
- United Arab Emirates University