Nipah virus spillover and transmission in Asia for targeted management strategies- A systematic review protocol

Introduction Nipah virus (NiV) is a zoonotic pathogen that poses a significant public health threat in Southeast and South Asia, with case fatality rates ranging from 40% to 100%. This systematic review aims to identify key transmission and spillover patterns and management strategies to help in prioritizing resource allocation and intervention. Methods and analysis This systematic review will be conducted following PRISMA guidelines. The search will encompass multiple electronic databases, including PubMed, Embase, and Scopus, up to 2024. Study selection, data extraction, and quality assessment will be performed by three independent reviewers, with a fourth reviewer resolving any disagreements. Data will be synthesized to identify patterns in transmission dynamics and inform targeted management strategies. Ethics and dissemination Ethical approval was not required as no human participants were involved. The systematic review will be published in an appropriate scientific journal. Registration details This systematic review has been registered on PROSPERO with registration ID CRD42024546848.