Intertwined Relationship of WWOX and RUNX2 Proteins as a Biomarker for Predicting Response and Survival in Patients With Childhood Bone Cancer in North India: A Pilot Study

These findings suggest that RUNX2 overexpression is a defining characteristic of ES and may contribute to tumor progression and metastasis. In contrast, WWOX does not appear to play a critical role in ES pathogenesis. The advanced stage at presentation and poor survival outcomes underscore the need for earlier detection and biomarker-driven interventions. Further research is warranted to validate RUNX2 as a prognostic biomarker and potential therapeutic target in ES.