The rechallenge benefit score: A clinical decision tool for patients progressing after immunotherapy

We identified and validated the RBS score to select patients likely to benefit from ICI rechallenge. Since clinical features alone are insufficient, our findings may guide treatment strategies for patients who experienced disease progression during prior ICI treatment.

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Publication Details

Journal
European Journal of Cancer
Published
2025-11-20
DOI
https://doi.org/10.1016/j.ejca.2025.116115
Primary Topic
Pregnancy and Medication Impact
Type
article
Field-Weighted Citation Impact
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article

The rechallenge benefit score: A clinical decision tool for patients progressing after immunotherapy

Emmanuel Grolleau, C. Decroisette, David Planchard, Caroline Plazy et al.
European Journal of Cancer
Pregnancy and Medication Impact
article

The rechallenge benefit score: A clinical decision tool for patients progressing after immunotherapy

Emmanuel Grolleau, C. Decroisette, David Planchard, Caroline Plazy, M. Pérol, Youssef Oulkhouir, V. Gounant, Sébastien Benzekry, Anthony Canellas, Anne-Claire Toffart, Élisa Gobbini, Linh Nguyen Phuong, Catherine Daniel, Éric Dansin, Baptiste Brette Jean, Mohamed Boussena
article en

Abstract

We identified and validated the RBS score to select patients likely to benefit from ICI rechallenge. Since clinical features alone are insufficient, our findings may guide treatment strategies for patients who experienced disease progression during prior ICI treatment.

European Journal of CancerVol. 232
Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris-Est Créteil (FR), Centre Hospitalier Universitaire de Grenoble (FR), Institut Gustave Roussy (FR), Sorbonne Université (FR), Hôpital Cochin (FR), Assistance Publique – Hôpitaux de Paris (FR), Hospices Civils de Lyon (FR), Centre Léon Bérard (FR), Centre Inria d'Université Côte d'Azur (FR), Hôpital Lyon Sud (FR), Centre Hospitalier Universitaire de Caen Normandie (FR), Centre de Recherche en Cancérologie de Lyon (FR), Centre Oscar Lambret (FR), Centre Hospitalier Régional Universitaire de Brest (FR), Hôpital Ambroise-Paré (FR), Centre Hospitalier Annecy Genevois (FR), Translational Innovation in Medicine and Complexity (FR), UniCancer Group (FR), Centre de Recherche en Cancérologie de Marseille (FR), Hôpital Bichat-Claude-Bernard (FR), Hôpital Tenon (FR), THERANOSCAN : Biomarqueurs Théranostiques des Cancers Bronchiques Non à Petites Cellules, Centre d'Investigation Clinique Bichat, Université de Rouen Normandie (FR), Institut Curie (FR), Université Grenoble Alpes (FR), Université de Caen Normandie (FR)
Openalex Percentile: Top 65%
Pregnancy and Medication Impact
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