Global epidemiology and resistance-related mutations of ceftazidime-avibactam-resistant Klebsiella pneumoniae strains
The combination of multiple drug resistance-related mutations leads to resistance to CAZ/AVI. The most common resistance-related mutations in strains from both public databases and those collected by our team are the coexistence of outer membrane porins and efflux pump mutations, and carriage of MBLs genes.
Authors
- Yuan Liu (ORCID: https://orcid.org/0000-0002-9622-6471)
- Xuelian Wu (ORCID: https://orcid.org/0000-0002-5445-6017)
- Yue Yuan (ORCID: https://orcid.org/0000-0001-8064-556X)
- Xinya Xie (ORCID: https://orcid.org/0000-0001-9710-9878)
- Jason M. Long (ORCID: https://orcid.org/0000-0001-6268-0943)
- Xiangzhao Meng (ORCID: https://orcid.org/0000-0003-0550-7786)
- Changjun Wang (ORCID: https://orcid.org/0000-0003-0420-4679)
- Xiong Liu (ORCID: https://orcid.org/0000-0001-7418-6694)
- Yong Chen (ORCID: https://orcid.org/0000-0002-6244-0197)
- Jiali Chen (ORCID: https://orcid.org/0000-0002-3101-104X)
- Jie Liu (ORCID: https://orcid.org/0000-0002-5354-9633)
- Jinpeng Guo (ORCID: https://orcid.org/0000-0001-8162-3004)
- Lihua Qi (ORCID: https://orcid.org/0000-0003-1249-037X)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Beijing Aerospace General Hospital (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Southern Medical University (CN)
- China Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fcimb.2025.1645042
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.36
Funders
- National Natural Science Foundation of China