Genistein mitigates ovarian dysfunction in a PCOS mouse model by regulating steroidogenesis, apoptosis, and PARP-1 signaling
These findings support genistein as a potential therapeutic agent for PCOS, targeting the PARP-1-pADPr axis and apoptosis. Further studies are needed to explore upstream mechanisms and evaluate its long-term effects on reproductive health.
Authors
- Guoyun Wu (ORCID: https://orcid.org/0000-0002-3053-931X)
- Xiaojuan Wan (ORCID: https://orcid.org/0000-0003-3289-8524)
- Mahmoud M. Azzam (ORCID: https://orcid.org/0000-0001-9736-5468)
- Tingting Gou
- Wenqian Li (ORCID: https://orcid.org/0000-0002-1000-2689)
- Qiuxian Meng
- Jin Wang
- Fenglan Lu
- Zhuoqian Guo
- Muhammad Faheem Akhta
Institutions
- Nanchang University (CN)
- Liaocheng University (CN)
- King Saud University (SA)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Agricultural University (CN)
Publication Details
- Journal
- Reproduction Fertility and Development
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1071/rd25126
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00