SIRT2-ANXA2 Axis in Donafenib Resistance: Promising Mechanistic Insight Demands Contextual and Translational Scrutiny

In their seminal study, Sun et al. delineate a novel pathway wherein SIRT2-mediated deacetylation of ANXA2 promotes protective autophagy, thereby conferring resistance to donafenib in hepatocellular carcinoma (HCC). This work provides a compelling mec

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Publication Details

Published
2025-09-25
DOI
https://doi.org/10.22541/au.175877299.91114247/v1
Primary Topic
Sirtuins and Resveratrol in Medicine
Type
article
Field-Weighted Citation Impact
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article

SIRT2-ANXA2 Axis in Donafenib Resistance: Promising Mechanistic Insight Demands Contextual and Translational Scrutiny

DuJiang Yang, Jiexiang Yang, GuoYou Wang, Zhijun Ye
Sirtuins and Resveratrol in Medicine
article

SIRT2-ANXA2 Axis in Donafenib Resistance: Promising Mechanistic Insight Demands Contextual and Translational Scrutiny

DuJiang Yang, Jiexiang Yang, GuoYou Wang, Zhijun Ye
article en

Abstract

In their seminal study, Sun et al. delineate a novel pathway wherein SIRT2-mediated deacetylation of ANXA2 promotes protective autophagy, thereby conferring resistance to donafenib in hepatocellular carcinoma (HCC). This work provides a compelling mec

Southwest Medical University (CN)
Openalex Percentile: Top 68%
Sirtuins and Resveratrol in Medicine
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SIRT2-ANXA2 Axis in Donafenib Resistance: Promising Mechanistic Insight Demands Contextual and Translational Scrutiny — DuJiang Yang, Jiexiang Yang, et al. · (2025) | TGRS Research Map | TGRS