Extracellular Vesicle-Derived Adenosine as a Diagnostic Metabolic Biomarker for Pancreatic Ductal Adenocarcinoma
The integration of EV metabolomics and proteomics revealed enhanced purine metabolism, particularly elevated extracellular adenosine, as a distinctive hallmark of PDAC. EV-derived adenosine emerges as a highly promising non-invasive biomarker with superior diagnostic accuracy compared to CA19-9.
Authors
- Xia Tao (ORCID: https://orcid.org/0000-0002-9369-6777)
- Wenbin Ouyang (ORCID: https://orcid.org/0000-0003-1928-1765)
- Zhengquan Yang
- Hezhi Fang (ORCID: https://orcid.org/0000-0003-0956-3160)
- Jie Wang (ORCID: https://orcid.org/0000-0003-2197-9265)
- Shanying Gui
- Jinjing Wang (ORCID: https://orcid.org/0000-0001-6668-0713)
- Yiping Mou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Zhejiang Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-09-24
- DOI
- https://doi.org/10.4143/crt.2025.510
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province