Advantages of MabSelect VH3, a novel VH3-specific Protein A resin, over its two conventional counterparts in purifying a VHH-based trispecific antibody
MabSelect VH3 is particularly suitable for the purification of bispecific antibodies and TsAbs, where the product and byproducts contain different numbers of VH3 domains. For multispecific antibody purification, screening different affinity resins with distinct binding specificity is recommended, as this can help identify the most effective option for separation.
Authors
- Dongdong Fang (ORCID: https://orcid.org/0000-0002-8556-1557)
- Wei Dong Qi (ORCID: https://orcid.org/0000-0002-7378-1392)
- Yifeng Li (ORCID: https://orcid.org/0009-0002-6994-9276)
Institutions
- WuXi AppTec (China) (CN)
Publication Details
- Journal
- Journal of Biological Methods
- Published
- 2025-09-19
- DOI
- https://doi.org/10.14440/jbm.0138
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81