Results of immunological control in orthodontic treatment of patients with chronic herpetic infection of the oral mucosa

The study is devoted to the complex therapy of chronic herpetic gingivostomatitis, the purpose of which was to increase the effectiveness of treatment of the disease in patients undergoing orthodontic treatment with aligners. It presents data on treatment methods, results of immunological control and conclusions on the effectiveness of therapy in 112 patients undergoing long-term orthodontic treatment with aligners. Patients were divided into two groups: the main group (59 people) and the control group (53 people). The main group, in addition to etiotropic treatment, received physiotherapy. Immunomodulatory therapy in the main group included the drug Meglumine acridonacetate, and in the control group, the drug Imudon. During immunological control, the activity of lysozyme and the level of secretory immunoglobulin A in saliva, as well as the level of IgG antibodies to the herpes simplex virus were measured. After processing the laboratory data, it was concluded that the main group showed more pronounced improvements compared to the control group in both lysozyme activity and s-IgA levels, and the level of IgG antibodies to the herpes simplex virus significantly decreased in the main group 2 months and 6 months after treatment compared to the control group. Treatment in the main group was more effective: it contributed to faster healing and a decrease in the level of antibodies to the virus. The results emphasize the importance of using a comprehensive approach to the treatment of herpes infection and monitoring the immune response.