Restoration of pancreatic beta cell identity and autophagy in KATP-induced diabetes by intermittent fasting
This study provides the first evidence of autophagy impairment in non-obese, insulin secretory-deficient, K<sub>ATP</sub>-induced diabetes mice and demonstrates that IF restores both autophagic flux and beta cell identity. This finding suggests that similar mechanisms may contribute to beta cell dysfunction in other forms of diabetes.
Authors
- Zihan Yan (ORCID: https://orcid.org/0000-0001-5298-4839)
- Sophia X. Chen (ORCID: https://orcid.org/0000-0002-7070-3970)
- Esmeralda Castelblanco
- Abhinav Diwan (ORCID: https://orcid.org/0000-0001-7554-4772)
- Zeenat A. Shyr (ORCID: https://orcid.org/0000-0001-8710-9938)
- Marı́a S. Remedi (ORCID: https://orcid.org/0000-0003-2048-472X)
- Irving Ramirez-Sotero
Institutions
- Washington University in St. Louis (US)
- John Cochran VA Medical Center (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-09-25
- DOI
- https://doi.org/10.1007/s00125-025-06545-w
- Citations
- 1
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 1.16