Administering a Second Dose of Intravenous Tenecteplase in Acute Ischemic Stroke: Rationale and Design of a Pilot Clinical Trial

We propose the first study of 2 sequential doses of TNK in patients with stroke. If successful, this study will be followed by a larger phase 2b controlled safety confirmation and pilot efficacy study.

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Publication Details

Journal
Stroke Vascular and Interventional Neurology
Published
2025-09-24
DOI
https://doi.org/10.1161/svin.125.002022
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Administering a Second Dose of Intravenous Tenecteplase in Acute Ischemic Stroke: Rationale and Design of a Pilot Clinical Trial

James C. Grotta
Stroke Vascular and Interventional Neurology
Acute Ischemic Stroke Management
article

Administering a Second Dose of Intravenous Tenecteplase in Acute Ischemic Stroke: Rationale and Design of a Pilot Clinical Trial

James C. Grotta
article en

Abstract

We propose the first study of 2 sequential doses of TNK in patients with stroke. If successful, this study will be followed by a larger phase 2b controlled safety confirmation and pilot efficacy study.

Stroke Vascular and Interventional NeurologyVol. 5(6)
Memorial Hermann (US)
Openalex Percentile: Top 65%
Acute Ischemic Stroke Management
DOIOpen Access PDFOpenAlex
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Administering a Second Dose of Intravenous Tenecteplase in Acute Ischemic Stroke: Rationale and Design of a Pilot Clinical Trial — James C. Grotta · Stroke Vascular and Interventional Neurology (2025) | TGRS Research Map | TGRS