Variants of unknown significance in fetal heart malformations: distribution and impact on prenatal decision-making
Fetuses with cardiac malformations accompanied by structural extracardiac anomalies carry the highest genetic risk; karyotyping combined with CMA should therefore be performed routinely. Complex cardiac malformations also warrant concurrent testing, whereas simple malformations and those with soft markers can be evaluated individually.
Authors
- Xianmin Wang (ORCID: https://orcid.org/0000-0003-3480-8780)
- Caiyu Guo
- Weiyi Wan
- Qingsong Wang (ORCID: https://orcid.org/0000-0003-2530-4038)
- Huang‐Tz Ou (ORCID: https://orcid.org/0000-0002-5475-7848)
- Xiaomeng Zhang (ORCID: https://orcid.org/0000-0003-2504-8599)
- Jun Yin
- Yang Cao (ORCID: https://orcid.org/0000-0002-0388-9496)
- Yundong Zhang
- Fuyan Li (ORCID: https://orcid.org/0000-0002-5020-5237)
- Tongyong Luo
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Women's and Children's Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fped.2025.1605899
- Citations
- 1
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35