Development and Validation of a High-performance Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Adrenocortical Hormones and Establishment of Age-stratified Reference Intervals in Reproductive-aged Women from Guangxi, China
We developed an HPLC-MS/MS-based method for simultaneously quantifying eight adrenocortical hormones, including 11-OH A4, and defined age-specific reference intervals for reproductive-aged Chinese women. These findings advance the clinical utility of adrenocortical hormones in diagnosing and managing reproductive disorders.
Authors
- Ganqin Wang
- Pei Huang
- Tingwei Jin
- Shengzhu Huang (ORCID: https://orcid.org/0000-0002-0956-5097)
- Xuelian Qin
- Siyu Deng
- Zengnan Mo (ORCID: https://orcid.org/0000-0002-3047-3138)
- Jinghang Jiang (ORCID: https://orcid.org/0000-0001-7019-5307)
- Yu Ye (ORCID: https://orcid.org/0000-0002-7025-436X)
- Yu Long
- Yonghua Jiang
- Jie Zheng (ORCID: https://orcid.org/0000-0002-8250-7061)
- Yingdan Nong
- Fan Wu
- Boteng Yan
- Yixuan Liu
- J Li
- Yong-Hua Wei
Institutions
- Guangxi Medical University (CN)
- First People’s Hospital of Jingmen (CN)
- Guangxi Science and Technology Department (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangxi Maternal and Child Health Hospital (CN)
- The Second Nanning People's Hospital (CN)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
- Center for Genomic Science (IT)
Publication Details
- Journal
- Annals of Laboratory Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3343/alm.2025.0090
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00