Centromere Protein I, a Cell Cycle Checkpoint Gene, Accelerates Tumor Progression via the Hippo Pathway and Mediates Immune Escape in Hepatocellular Carcinoma
This study underscores the prognostic significance of CCCRGs in HCC and identifies CENPI as a key driver of tumor progression through the Hippo pathway. Furthermore, it reveals CENPI's role in promoting immune escape, suggesting novel therapeutic targets for HCC treatment.
Authors
- Jian Ma (ORCID: https://orcid.org/0000-0001-8223-8327)
- Risheng He (ORCID: https://orcid.org/0000-0001-9214-5968)
- Yunfu Cui (ORCID: https://orcid.org/0000-0001-7393-1680)
- Pengbo Zhang (ORCID: https://orcid.org/0000-0002-8519-3125)
- Yu Liang (ORCID: https://orcid.org/0000-0002-1927-4875)
- Yi Xu (ORCID: https://orcid.org/0000-0002-5361-1812)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- First People's Hospital of Yunnan Province (CN)
- Shanghai Cancer Institute (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- The First People's Hospital of Zhaoqing (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.14218/jcth.2025.00127
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00