Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms
Exercise increases EPI levels, activates the Wnt signaling pathway through β2 receptors, enhances the Wnt1-Lmx1a regulatory loop, and promotes the differentiation of iPSCs into dopaminergic neurons, thereby increasing the number of neurons.
Authors
- Zhimin Lu (ORCID: https://orcid.org/0000-0002-2859-2736)
- Xing Jiang
- Qinglu Wang (ORCID: https://orcid.org/0000-0002-2891-9399)
- Jie Zhang (ORCID: https://orcid.org/0009-0002-3533-6877)
- Ying Luo (ORCID: https://orcid.org/0000-0002-9974-6368)
Institutions
- Qilu University of Technology (CN)
- Shandong Sport University (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-09-24
- DOI
- https://doi.org/10.4252/wjsc.v17.i9.109330
- Citations
- 2
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.82