Study design and protocol of a randomized, pragmatic, comparative effectiveness trial evaluating a sequenced strategy for improving outcomes in people with knee osteoarthritis pain (SKOAP): Conservative treatment evaluation
Findings from Phase 1 of the SKOAP trial will provide evidence on the effectiveness of non-opioid pharmacologic and psychological interventions for the treatment of painful KOA beyond established best practices. It may also help refine personalized treatment strategies.
Authors
- Ron Reeder (ORCID: https://orcid.org/0000-0003-0021-5944)
- Jordan Bridges
- R. Castillo (ORCID: https://orcid.org/0000-0003-0473-5891)
- Jennifer A. Haythornthwaite (ORCID: https://orcid.org/0000-0002-5924-7580)
- Daniel O. Scharfstein (ORCID: https://orcid.org/0000-0001-7482-9653)
- Stephen T. Wegener (ORCID: https://orcid.org/0000-0002-0867-2229)
- Daniel F. Hanley (ORCID: https://orcid.org/0000-0002-9536-4258)
- Robert W. Hurley (ORCID: https://orcid.org/0000-0001-6591-9390)
- Steven Paul Cohen (ORCID: https://orcid.org/0000-0001-5928-2127)
- Claudia M. Campbell (ORCID: https://orcid.org/0000-0002-5420-4207)
- Francis J. Keefe (ORCID: https://orcid.org/0000-0003-0583-9326)
- Srinivasa N. Raja (ORCID: https://orcid.org/0000-0001-7991-7636)
- Melinda M. Holena
- Lauren Allen (ORCID: https://orcid.org/0000-0002-8097-4555)
- Shuzhi Zhao (ORCID: https://orcid.org/0000-0003-3307-7808)
- Richard E. Thompson (ORCID: https://orcid.org/0000-0003-2561-5522)
- Heavon M Allen
- Christine Rini
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
- Duke University (US)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- Behavioral Pharma (United States) (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Wake Forest University (US)
Publication Details
- Journal
- Seminars in Arthritis and Rheumatism
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.semarthrit.2025.152834
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00