Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis
This study establishes a shared genetic and immunological basis for SS and AAA, driven primarily by dysregulated HLA-mediated antigen presentation (HLA-B/HLA-DR), spliceosome dysfunction, and NK cell impairment. These findings provide mechanistic insights for early AAA detection in SS patients and support developing immunotherapies targeting HLA pathways.
Authors
- Qinghua Luo (ORCID: https://orcid.org/0000-0003-4488-2394)
- Jun Yong He (ORCID: https://orcid.org/0000-0001-8056-0347)
- Ya Zhou (ORCID: https://orcid.org/0000-0002-4789-2435)
- Zhaohui Ding (ORCID: https://orcid.org/0000-0003-3051-1111)
- Lihua Wang (ORCID: https://orcid.org/0000-0003-2782-4010)
- Hao Xiong (ORCID: https://orcid.org/0000-0002-7619-4740)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fcvm.2025.1554991
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00