Pericoronary adipose tissue inflammation mediates the atherogenic effects of lipids on multivessel coronary artery disease: a CCTA-based radiomics analysis
This is the first study to demonstrate that coronary arterial inflammation (RCA-FAI) partially mediates the atherogenic effects of AIP on MVCAD, suggesting a dual pathway of lipid-driven inflammation and metabolic dysregulation. Our findings highlight RCA-FAI as a promising imaging biomarker for CAD risk stratification, irrespective of glucose metabolism status.
Authors
- Qin Zhou (ORCID: https://orcid.org/0000-0001-6549-4740)
- Jieming Zheng
- Yao Yao (ORCID: https://orcid.org/0000-0002-0879-4269)
- Linjuan Li
- Haimei Du
Institutions
- Yan'an University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fcvm.2025.1629984
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Natural Science Foundation of Shaanxi Province
- Yan'an Science and Technology Bureau