Hierarchical biomechanical characterisation of riboflavin-UVA crosslinking and decorin treatment in the porcine cornea
The results imply the bulk stiffening caused by crosslinking was not primarily due to increases in fibril stiffness. Instead, trends in bulk fibril reorientation and straightening/uncrimping imply the stiffening is attributable to enhanced interconnectivity of the fibrillar stroma, leading to greater fibril recruitment fraction. The techniques reported here are applicable to a wide range of tissues for the evaluation of new, existing and adjuvant therapies.
Authors
- Samuel Lewin Evans (ORCID: https://orcid.org/0000-0003-3664-2569)
- Craig Boote (ORCID: https://orcid.org/0000-0003-0348-6547)
- Olga Shebanova (ORCID: https://orcid.org/0000-0003-4093-2083)
- Shethah Morgan
- Keith M. Meek (ORCID: https://orcid.org/0000-0002-9948-7538)
- Sally Hayes (ORCID: https://orcid.org/0000-0001-8550-0108)
- Nicholas J. Terrill (ORCID: https://orcid.org/0000-0002-8783-1282)
- J. S. Bell (ORCID: https://orcid.org/0000-0001-8371-9851)
Institutions
- Diamond Light Source (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fbioe.2025.1603679
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diamond Light Source
- Medical Research Council