Multi-omics profiling identifies M1 macrophage polarization-associated biomarkers in hepatitis B virus-related acute-on-chronic liver failure
This study identifies CDC20, CXCL14, FCGR2B, HKDC1, and GPBAR1 as M1 polarization-associated biomarkers, revealing their roles in immune-metabolic dysregulation and proposing novel therapeutic strategies for HBV-ACLF.
Authors
- Chengxi Sun (ORCID: https://orcid.org/0000-0002-1050-5956)
- Qianli Dong (ORCID: https://orcid.org/0000-0001-9577-812X)
- Shuai Gao (ORCID: https://orcid.org/0000-0002-8208-9197)
- Heng Wang (ORCID: https://orcid.org/0000-0002-1727-9226)
- Jianguo Hong
- Cheng Li
- Helgi B. Schiöth
- Wencheng Lv (ORCID: https://orcid.org/0000-0003-4617-958X)
- Zeyang Liu (ORCID: https://orcid.org/0000-0001-6849-8675)
Institutions
- Uppsala University (SE)
- Shandong University (CN)
- Shanghai East Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fmicb.2025.1630042
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00