MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report
Extremely high-dose metoclopramide, particularly in combination with other drugs, can cause a characteristic symmetrical white matter injury pattern of toxic encephalopathy, with MRI findings offering high diagnostic value. Early recognition, prompt gastrointestinal decontamination, blood purification, and multi-target neuroprotective therapy can markedly improve prognosis.
Authors
- Qiming Fang (ORCID: https://orcid.org/0000-0002-4751-3765)
- Yuncheng Tang
- Xuefang Liu (ORCID: https://orcid.org/0000-0001-6000-0529)
- Zhiwen Zhao (ORCID: https://orcid.org/0000-0003-2319-6416)
- Zeyu Wu (ORCID: https://orcid.org/0000-0001-6504-5734)
- Pengfei Liang (ORCID: https://orcid.org/0000-0001-5128-1509)
- Juan Zhao (ORCID: https://orcid.org/0000-0002-1809-3124)
- Xiaolin Zhang (ORCID: https://orcid.org/0000-0002-9875-1931)
- Li Zhang (ORCID: https://orcid.org/0000-0002-0430-2749)
- Haowen Tang
- Zhicheng Fang (ORCID: https://orcid.org/0000-0003-2800-0806)
Institutions
- Hubei University of Medicine (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fphar.2025.1683132
- Citations
- 3
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41