Multi-pathway mechanisms of Liujunzi decoction in promoting glioma apoptosis and reversing drug resistance: network pharmacology and experimental validation
LJZD may exert anti-glioma effects by inducing tumor cell apoptosis and overcoming drug resistance, potentially serving as an adjuvant to enhance conventional therapies. Additionally, its active ingredients (e.g., glabridin, pinocembrin and chrysophanol) provide novel leads for developing small-molecule therapeutics.
Authors
- Luning Xu (ORCID: https://orcid.org/0000-0003-2647-6130)
- Jinxiang Huang (ORCID: https://orcid.org/0000-0002-7703-5645)
- Shengnan Lin
- Lin Lei (ORCID: https://orcid.org/0000-0001-6687-6898)
- Dezhi Kang (ORCID: https://orcid.org/0000-0003-0300-9660)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Sanming University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fphar.2025.1682550
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province