Paederoside, an active metabolite of Paederia scandens, alleviates osteoporosis by modulating Wnt/β-catenin signaling
In conclusion, <i>P. scandens</i> exerts protective effects against osteoporosis, and paederoside, identified as a primary plasma-absorbed metabolite, enhances osteoblastogenesis and suppresses osteoclastogenesis, likely through the upregulation of the Wnt/β-catenin signaling pathway. This study elucidates the health benefits of <i>P. scandens</i> and paederoside in the prevention and treatment of osteoporosis.
Authors
- Xintao Wang (ORCID: https://orcid.org/0009-0002-8213-0556)
- Mu Jiang
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Jingwei Zhang (ORCID: https://orcid.org/0000-0002-4955-769X)
- Weitao He
- Bo Su (ORCID: https://orcid.org/0000-0002-7309-8083)
Institutions
- Harbin Medical University (CN)
- Dalian Municipal Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fphar.2025.1670279
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Heilongjiang Province
- Fundamental Research Funds for the Central Universities