Mesenchymal stem cell-conditioned medium accelerates type 2 diabetic wound healing by targeting TNF and chemokine signaling
ACM promotes diabetic wound healing through dual mechanisms: (1) stimulating vascularization by inducing growth factor expression and (2) modulating the inflammatory microenvironment by inhibiting TNF/chemokine cascades. These findings position ACM as a promising cell-free therapy for impaired wound healing in diabetes.
Authors
- Xiankun Lin (ORCID: https://orcid.org/0000-0001-6936-4812)
- Naishun Liao (ORCID: https://orcid.org/0000-0002-2781-4229)
- Xiaodan Wu (ORCID: https://orcid.org/0000-0002-0812-7546)
- Haiyun Liu (ORCID: https://orcid.org/0000-0002-0485-2695)
- Long Huang (ORCID: https://orcid.org/0000-0003-4925-5162)
- Zhongbao Lin
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fcell.2025.1659444
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00