Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort
These results establish obesity-associated adipose tissue dysregulation as a key intertissue modulator of biology, with concordant cross-species effects on tumor cell-intrinsic inflammatory and metabolic programs.
Authors
- Aik Choon Tan (ORCID: https://orcid.org/0000-0003-2955-8369)
- Elaine M. Glenny (ORCID: https://orcid.org/0000-0002-1024-4290)
- Doratha A. Byrd (ORCID: https://orcid.org/0000-0003-4275-7901)
- Jane C. Figueiredo (ORCID: https://orcid.org/0000-0001-8040-3341)
- David Shibata (ORCID: https://orcid.org/0000-0002-5670-423X)
- Jolanta Jedrzkiewicz (ORCID: https://orcid.org/0000-0002-9408-3139)
- Sheetal Hardikar (ORCID: https://orcid.org/0000-0003-0292-6168)
- Alexander Brobeil (ORCID: https://orcid.org/0000-0002-1003-8577)
- Stephen David Hursting (ORCID: https://orcid.org/0000-0003-3605-2833)
- Christopher I. Li (ORCID: https://orcid.org/0000-0003-1543-0743)
- Caroline Himbert (ORCID: https://orcid.org/0000-0003-4084-8340)
- Biljana Gigic (ORCID: https://orcid.org/0000-0002-8085-2072)
- David A. Nix (ORCID: https://orcid.org/0009-0002-3383-8582)
- Ildiko Strehli (ORCID: https://orcid.org/0000-0003-1127-2186)
- Michael F. Coleman (ORCID: https://orcid.org/0000-0002-6914-848X)
- Christoph Kahlert (ORCID: https://orcid.org/0000-0003-4124-7918)
- Олена Федорівна Аксьонова (ORCID: https://orcid.org/0000-0003-4666-9271)
- Erin M. Siegel (ORCID: https://orcid.org/0000-0003-1779-2510)
- Jessica N. Cohan (ORCID: https://orcid.org/0000-0002-5461-4716)
- Tengda Lin (ORCID: https://orcid.org/0000-0001-5147-8432)
- Christy A. Warby (ORCID: https://orcid.org/0000-0003-1772-8332)
- Victoria M. Bandera
- Saratchandra Singh Khumukcham (ORCID: https://orcid.org/0000-0001-5632-3341)
- Kenneth M. Boucher (ORCID: https://orcid.org/0000-0003-2833-0127)
- Jennifer Ose (ORCID: https://orcid.org/0000-0002-2030-9676)
- C. Busch (ORCID: https://orcid.org/0009-0004-2617-337X)
- Jatin Roper (ORCID: https://orcid.org/0000-0002-8851-1352)
- Adetunji T. Toriola (ORCID: https://orcid.org/0000-0003-1079-2606)
- Alessandro Carpanese
- Martin Schneider (ORCID: https://orcid.org/0000-0002-8864-6492)
- Peter Schirmacher
- Cornelia M. Ulrich
- Babak Mirminachi
Institutions
- University of North Carolina at Chapel Hill (US)
- Cedars-Sinai Medical Center (US)
- University of Tennessee Health Science Center (US)
- Duke University (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- Heidelberg University (DE)
- Huntsman Cancer Institute (US)
- University Hospital Heidelberg (DE)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.09.031
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00