Multiomics analysis reveals early administration of the Medhya rasayana formulation of Bacopa monnieri (L.) Wettst. and Centella asiatica (L.) Urb. prevents neuroinflammation and cognitive deficits in an AβO-injected AD mouse model
Our findings indicate that pretreatment with Bm and Ca rasayana prevents AβO-induced neuroinflammation and cognitive deficits in an AD mouse model by suppressing proinflammatory pathways and restoring redox balance, suggesting its potential for delaying the onset of disease progression.
Authors
- Kanive Parashiva Guruprasad (ORCID: https://orcid.org/0000-0003-1597-1152)
- Amit Kumar Goyal (ORCID: https://orcid.org/0000-0003-2403-5323)
- Swathi Maruthiyodan
- Anita Mahadevan (ORCID: https://orcid.org/0000-0002-4837-1463)
- Kamalesh Dattaram Mumbrekar (ORCID: https://orcid.org/0000-0003-1888-6252)
- Gireesh Gangadharan (ORCID: https://orcid.org/0000-0001-9369-319X)
- Manjunath B. Joshi (ORCID: https://orcid.org/0000-0002-1310-5480)
- M. Thomas
- Muraleedharan Ts
- Valiathan Ms
- Gagan Munegowda
- Anandan Em
Institutions
- Manipal Academy of Higher Education (IN)
- Arya Vaidya Sala (IN)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jep.2025.120633
- Citations
- 1
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 2.38