Redefining Ischemic Core, Penumbra, and Target Mismatch on Perfusion Imaging in Acute Anterior Distal Medium Vessel Occlusion
In acute anterior DMVOs, rCBF <38% and Tmax >8 s best correspond to ischemic core and penumbra, respectively; more favorably quantify LVO TMM; and reveal optimal TMM criteria. These results should be prospectively investigated as inclusion criteria for EVT in this population and suggest recent negative DMVO EVT trials may have been confounded by suboptimal patient selection.
Authors
- Meisam Hoseinyazdi (ORCID: https://orcid.org/0000-0002-4051-2946)
- Jeremy Josef Heit (ORCID: https://orcid.org/0000-0003-1055-8000)
- Argye E. Hillis (ORCID: https://orcid.org/0000-0002-5192-1171)
- R. Llinás (ORCID: https://orcid.org/0000-0002-9161-2699)
- Richard Leigh (ORCID: https://orcid.org/0000-0002-8285-1815)
- Gregory W. Albers (ORCID: https://orcid.org/0000-0003-0263-4632)
- Hamza Adel Salim (ORCID: https://orcid.org/0000-0002-5208-8425)
- Dhairya A. Lakhani (ORCID: https://orcid.org/0000-0001-7577-1887)
- Adam Andrew Dmytriw (ORCID: https://orcid.org/0000-0003-0131-5699)
- Janet Y. Mei (ORCID: https://orcid.org/0000-0003-4184-8924)
- Jens Fiehler (ORCID: https://orcid.org/0000-0001-8533-7478)
- Shyam Majmundar (ORCID: https://orcid.org/0000-0001-6867-2485)
- Victor Urrutia (ORCID: https://orcid.org/0000-0002-4995-6949)
- Elisabeth B. Marsh (ORCID: https://orcid.org/0000-0002-2385-5074)
- Vivek Srikar Yedavalli (ORCID: https://orcid.org/0000-0002-2450-4014)
- Leon Y. Cai (ORCID: https://orcid.org/0000-0002-5812-5397)
- Thanh N. Nguyen
- Adrien Guenego
- Tobias D. Faizy
Institutions
- Boston University (US)
- West Virginia University (US)
- University of Maryland, Baltimore (US)
- Brigham and Women's Hospital (US)
- University of Maryland Medical Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Universität Hamburg (DE)
- Johns Hopkins Medicine (US)
- Erasmus Hospital (BE)
- University Hospital Münster (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Stanford University (US)
Publication Details
- Journal
- Stroke Vascular and Interventional Neurology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1161/svin.125.001900
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71