Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice
GKA inhibits TFE3 phosphorylation via DYRK1A, thereby driving TFE3 nuclear translocation and activating autophagy, which suppresses ferroptosis in airway epithelial cells. This study identifies GKA as a therapeutic candidate for asthma, and screening of additional flavones will be valuable to map the structural features that confer this activity.
Authors
- Xiao-hua Ji
- Z. H. An (ORCID: https://orcid.org/0000-0002-9341-0505)
- Xiaoru Yan
- Xun Chen (ORCID: https://orcid.org/0009-0004-1465-3333)
- Jing‐Long Huang (ORCID: https://orcid.org/0000-0002-3530-7753)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3113-4015)
- Min Li (ORCID: https://orcid.org/0000-0002-7113-2700)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.157306
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00