Astragali radix - Curcumae rhizoma herb pair enhances Sorafenib's efficacy by inducing ferroptosis and activates Th1 cell immune response synergistically against hepatocellular carcinoma
ACHP enhances Sorafenib's efficacy by inducing lipid peroxidation-related ferroptosis and activates Th1-type anti-tumor immune responses, synergistically suppressing HCC. The study establishes a complete evidence chain of "component characterization-mechanism verification", providing novel therapeutic targets and strategic insights for the development of combination therapy for HCC.
Authors
- Huajun Zhao (ORCID: https://orcid.org/0000-0001-8643-4261)
- Hang Gao (ORCID: https://orcid.org/0000-0002-3403-1257)
- Chen Wang (ORCID: https://orcid.org/0000-0001-5291-3694)
- Zhihui Zhu (ORCID: https://orcid.org/0000-0002-3712-7238)
- Hongtao Hu (ORCID: https://orcid.org/0000-0003-3704-6646)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.157326
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52