Electroporation of 3D-Cultured Breast Cancer Cells Elicits T Lymphocyte-Mediated Killing
Background: Electrochemotherapy (ECT) is emerging as a powerful strategy to induce immunogenic cell death and profoundly reshape the tumor microenvironment. However, the specific immunomodulatory role of electric pulses, independently of chemotherapeutic agents, remains to be fully elucidated. This study investigates the potential of high-voltage electroporation, as used in ECT protocols, to stimulate immune responses in breast cancer.
Authors
- Elisabetta Sieni (ORCID: https://orcid.org/0000-0001-5297-0576)
- Annj Zamuner (ORCID: https://orcid.org/0000-0002-8113-0346)
- Ramona Marino
- Monica Dettin (ORCID: https://orcid.org/0000-0002-6823-3375)
- Emanuela Signori (ORCID: https://orcid.org/0000-0003-0286-7401)
- Mariangela De Robertis (ORCID: https://orcid.org/0000-0002-5409-639X)
- Maria Teresa Conconi (ORCID: https://orcid.org/0000-0003-1288-5013)
- Andrea Marra (ORCID: https://orcid.org/0000-0002-4724-9327)
- Mario Cioce (ORCID: https://orcid.org/0000-0001-8129-6664)
- Vincenzo Maria Perriello (ORCID: https://orcid.org/0000-0003-4105-9087)
- N. Martarelli (ORCID: https://orcid.org/0009-0003-1875-4345)
Institutions
- University of Insubria (IT)
- University of Padua (IT)
- Università Campus Bio-Medico (IT)
- University of Perugia (IT)
- Istituto di Farmacologia Traslazionale (IT)
- Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Bioelectricity
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1177/25763113251380149
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00