Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone
The anti-tumor effects of CCEO in triple-negative breast cancer (TNBC) are principally mediated by (+)-2-Bornanone, which inhibits the MAPK/ERK pathway via NOX4 downregulation. These findings reveal a novel anti-tumor mechanism and provide a strong rationale for further developing (+)-2-Bornanone as a promising natural therapeutic agent for BC treatment.
Authors
- Yidan Chen (ORCID: https://orcid.org/0000-0003-1791-7248)
- Lingrong Yang (ORCID: https://orcid.org/0000-0003-3042-0113)
- Ruzhen Zheng (ORCID: https://orcid.org/0009-0007-1140-9521)
- Rui Wang (ORCID: https://orcid.org/0009-0008-0900-4282)
- Hualing Xie
- Yibin Wang (ORCID: https://orcid.org/0000-0003-0852-0767)
- Shangnao Xie (ORCID: https://orcid.org/0000-0002-5154-6447)
- Yibo He (ORCID: https://orcid.org/0009-0000-4057-8577)
- Shiyan Wu
Institutions
- Zhejiang Shuren University (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.phymed.2025.157327
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00