Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer
These findings indicate that ALO may serve as a novel therapeutic candidate for gallbladder cancer by inhibiting autophagic flux to induce ROS-mediated apoptosis while activating the cGAS-STING-IFN pathway to enhance antitumor immunity.
Authors
- Hao Shen
- Xiujun Cai (ORCID: https://orcid.org/0000-0002-6457-0577)
- Yuxuan Shen (ORCID: https://orcid.org/0009-0001-1164-2071)
- Hui‐Hu Lu (ORCID: https://orcid.org/0000-0002-2363-962X)
- Yushun Chang
- Bo Yang (ORCID: https://orcid.org/0000-0002-3183-5567)
- Yifan Wang (ORCID: https://orcid.org/0000-0002-8828-4268)
- Weijun Zhao
- Yang Quan
- Jie Lin (ORCID: https://orcid.org/0009-0001-9124-9041)
- Wen Hua
Institutions
- Sir Run Run Shaw Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.intimp.2025.115590
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80