Genomic and transcriptomic analyses of residual invasive triple-negative breast cancer after neoadjuvant chemotherapy in the prospective MIRINAE trial (a randomized phase II trial of adjuvant atezolizumab plus capecitabine compared to capecitabine; K
Residual TNBCs after standard NAC were predominantly basal-like or MES/BLIS subtypes with variable tumor microenvironment (TME). Early recurrence was associated with immune-cold TME, and further analyses on each treatment arm will provide deeper insights into the role of adjuvant immunotherapy.
Authors
- Sung Hoon Sim (ORCID: https://orcid.org/0000-0002-1503-1075)
- W.-Y. Park
- Jangsup Moon (ORCID: https://orcid.org/0000-0003-1282-4528)
- J. Lee
- Kyong Hwa Park (ORCID: https://orcid.org/0000-0002-2464-7920)
- Sung‐Bae Kim (ORCID: https://orcid.org/0000-0001-5588-8332)
- G.M. Kim
- Joohyuk Sohn (ORCID: https://orcid.org/0000-0002-2303-2764)
- C. Park
- K.H. Jung
- Kabsoo Shin (ORCID: https://orcid.org/0000-0002-6709-0894)
- Keun Seok Lee (ORCID: https://orcid.org/0000-0001-5575-836X)
- In Hae Park (ORCID: https://orcid.org/0000-0001-7894-8772)
- Chan‐Young Ock (ORCID: https://orcid.org/0000-0002-6755-9728)
- Jin Woo Koh
- Kyunghee Park (ORCID: https://orcid.org/0000-0003-0511-4958)
- Moon‐Hyoung Lee (ORCID: https://orcid.org/0000-0002-7268-0741)
- Jee Hung Kim (ORCID: https://orcid.org/0000-0002-9044-8540)
- Seock‐Ah Im (ORCID: https://orcid.org/0000-0002-5396-6533)
- Ji‐Yeon Kim (ORCID: https://orcid.org/0000-0002-4223-1929)
- Kyu Eun Lee (ORCID: https://orcid.org/0000-0002-2354-3599)
- Hee Kyung Ahn (ORCID: https://orcid.org/0000-0001-7786-7233)
- A. Lee
- Jeoung Won Bae (ORCID: https://orcid.org/0000-0002-3975-7989)
- Han Jo Kim (ORCID: https://orcid.org/0000-0002-5721-1728)
- Dongho Lee (ORCID: https://orcid.org/0000-0003-4379-814X)
- Jee Hyun Kim (ORCID: https://orcid.org/0000-0003-1336-3620)
- Yeon Hee Park (ORCID: https://orcid.org/0000-0003-4156-9212)
- Seungtaek Lim (ORCID: https://orcid.org/0000-0001-7258-2263)
- Jae Ho Jeong (ORCID: https://orcid.org/0000-0002-8749-2612)
- Kyung-Hun Lee (ORCID: https://orcid.org/0000-0002-2390-3240)
- Heejung Chae (ORCID: https://orcid.org/0000-0003-3547-3521)
- Y.J. Cha
- KJ Suh
Institutions
- Ulsan College (KR)
- Ewha Womans University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Soonchunhyang University (KR)
- Severance Hospital (KR)
- Korea University Medical Center (KR)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- University of Ulsan (KR)
- Gachon University Gil Medical Center (KR)
- National Cancer Center (US)
- St. Mary's Hospital (US)
- Wonju Severance Christian Hospital (KR)
- National Cancer Center (KR)
- Gangnam Severance Hospital (KR)
- Inha University Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Korea University (JP)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105804
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00