Natural Mutation in Naked Mole‐Rat <scp>UCP</scp>1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis
The UCP1 variant of the NMR, a warm-adapted fossorial species, excludes the histidine pair motif as crucial for UCP1 thermogenic function. Collectively, we show that functional investigation into natural sequence variation of UCP1 not only casts new light on the thermophysiology of NMRs but also represents a powerful tool to delineate structure-function relationships underlying the enigmatic thermogenic proton transport of UCP1.
Authors
- Maria Kutschke
- Jane Reznick (ORCID: https://orcid.org/0000-0001-7921-5466)
- Paul G. Crichton (ORCID: https://orcid.org/0000-0003-3786-8359)
- Amanda Bundgaard (ORCID: https://orcid.org/0000-0001-9716-8333)
- Martin Jastroch (ORCID: https://orcid.org/0000-0003-0358-3865)
- Margeoux A. S. Dela Rosa (ORCID: https://orcid.org/0000-0002-9586-763X)
- Michael J. Gaudry (ORCID: https://orcid.org/0000-0001-8411-0415)
- Klaudia Ostatek (ORCID: https://orcid.org/0009-0001-0340-8648)
Institutions
- University of East Anglia (GB)
- Stockholm University (SE)
- Aarhus University (DK)
- Wenner-Gren Foundations (SE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1111/apha.70109
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk
- Vetenskapsrådet