Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification
We identified that an oxLDL-induced transcription factor FOXS1 inhibits ABCA1 and ABCG1 expression via the BSCL2/PPARγ/LXRα axis and promotes cholesterol transport dysfunction and the activation of NLRP3 inflammasome in VICs, thereby accelerating the progression of CAVD.
Authors
- Xingyu Qian
- Zheng Qiang (ORCID: https://orcid.org/0000-0002-2013-2372)
- Qiang Shen (ORCID: https://orcid.org/0000-0002-1491-5434)
- Dingyi Yao
- Fan Lin (ORCID: https://orcid.org/0000-0003-1577-3287)
- Yuming Huang (ORCID: https://orcid.org/0000-0001-8719-7077)
- Zongtao Liu (ORCID: https://orcid.org/0000-0001-6551-7797)
- Rui Tian (ORCID: https://orcid.org/0000-0002-2941-4050)
- Nianguo Dong (ORCID: https://orcid.org/0000-0001-5575-7084)
- Chen Jiang (ORCID: https://orcid.org/0000-0001-6910-4287)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Provincial Hospital (CN)
- Wuhan Union Hospital (CN)
- Hubei Cancer Hospital (CN)
- Fu Wai Hospital (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-21
- DOI
- https://doi.org/10.1093/cvr/cvaf159
- Citations
- 4
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China