Phenotyping of human platelets in response to platelet agonists and inhibitors using multiparameter flow cytometry and unbiased high-dimensional analysis
Platelet subpopulations are dynamic and undergo remodeling in response to different agonists and inhibitors. This high-dimensional single-cell flow cytometry assay is a practicable approach to evaluate the effects of agonists and inhibitors on platelet receptor expression and platelet subpopulations.
Authors
- Daisie M Yates (ORCID: https://orcid.org/0000-0001-7566-1653)
- Ann W Morgan (ORCID: https://orcid.org/0000-0003-1109-624X)
- James Robinson (ORCID: https://orcid.org/0000-0001-5425-7520)
- Elfrida R. Benjamin (ORCID: https://orcid.org/0000-0002-9708-8218)
- Khalid M. Naseem (ORCID: https://orcid.org/0000-0002-3870-8747)
- Lih T. Cheah (ORCID: https://orcid.org/0000-0002-2805-9931)
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Versiti Blood Center of Wisconsin (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.rpth.2025.103189
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77