Cysteine Restriction Induces Ferroptosis Depending on the S-adenosylmethionine and Polyamine Biosynthetic Pathways in Hepatic Cancer Cells
These results suggest that cysteine-glutathione and SAM-polyamine metabolic pathways are critical modulators of ferroptosis of hepatic cancer cells. Since normal liver cells were more resistant to ferroptosis than cancer cells, cysteine restriction may be exploited in treating hepatic cancer by inducing ferroptosis specifically in cancer cells without affecting normal cells in the liver.
Authors
- Akihiko Muto (ORCID: https://orcid.org/0000-0002-8538-022X)
- Daisuke Saigusa (ORCID: https://orcid.org/0000-0001-9484-9870)
- K MITSUYAMA
- Hiroki Shima (ORCID: https://orcid.org/0000-0001-8681-8337)
- Hironari Nishizawa (ORCID: https://orcid.org/0000-0001-7024-9942)
- Motoshi Wada (ORCID: https://orcid.org/0000-0003-0413-4017)
- Keisuke Tada (ORCID: https://orcid.org/0000-0003-1492-3888)
- Kazuhiko Igarashi (ORCID: https://orcid.org/0000-0002-2470-2475)
Institutions
- Tohoku University (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.gastha.2025.100817
- Citations
- 1
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81