May High Levels of Systemic Immune-inflammation Index Suggest a Further Stage in Seminomatous Testicular Germ Cell Tumors

Objective: This study aimed to investigate the relationship between preoperative systemic immune-inflammation index (SII) and postoperative tumor stage in patients with seminomatous testicular germ cell tumors.Materials and Methods: A total of 33 patients who underwent radical orchiectomy and were histopathologically diagnosed with seminoma were included in the study.Patients with tumors localized to the testis were designated as group 1, while those with extratesticular spread (advanced-stage tumors) were classified as group 2. Each group was then compared based on preoperative SII levels.Results: Group 1 consisted of 22 patients.The mean ages of groups 1 and 2 were 36.14 and 35.09 years, respectively, with no statistically significant difference between the groups (p>0.05).However, SII levels in group 2 were significantly higher than those in group 1, with a reported value of 924.70 (p=0.002).Moreover, a 10-unit increase in SII was found to increase the likelihood of advanced-stage tumors, with extratesticular spread, by approximately 6% (odds ratio =1.006). Conclusion:This study demonstrated that high preoperative SII is significantly associated with advanced tumor stage in patients with seminoma.