Cross-sectional associations of radiographic multiple joint osteoarthritis and symptoms, laboratory values and the gut microbiota: A multimodal study in humans and pet dogs
These two cohorts demonstrated remarkably similar frequencies of rMJOA (∼20 %), supporting the use of dogs to model naturally occurring MJOA. Taxa potentially related to rMJOA and pain were identified in this preliminary analysis, providing new insights into links between dysbiosis and MJOA.
Authors
- B. Duncan X. Lascelles (ORCID: https://orcid.org/0000-0002-2950-9009)
- Yvonne M. Golightly (ORCID: https://orcid.org/0000-0003-1205-2759)
- Savannah Aker
- Tessa Walker
- Christina Stevens (ORCID: https://orcid.org/0009-0005-9771-9007)
- Richard F. Loeser (ORCID: https://orcid.org/0000-0003-2832-6144)
- Milja Koskinen (ORCID: https://orcid.org/0009-0005-0217-3399)
- Serena Savage‐Guin
- M. Andrea Azcárate-Peril (ORCID: https://orcid.org/0000-0003-0325-1289)
- Jordan B. Renner (ORCID: https://orcid.org/0000-0003-2137-3052)
- Liubov S Arbeeva (ORCID: https://orcid.org/0000-0001-5004-419X)
- Amanda E. Nelson (ORCID: https://orcid.org/0000-0002-9344-7877)
- Masataka Enomoto (ORCID: https://orcid.org/0000-0003-2516-635X)
- Kelly Johnson
- Tracey Cole
- Connor Thonen-Fleck
Institutions
- University of North Carolina at Chapel Hill (US)
- Pain and Rehabilitation Medicine (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100682
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34