Long‐Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering—Laboratory Investigation
Long-term biobanked DPSCs preserve their angiogenic potential and, following extended endothelial induction, can independently generate vascularised tissue in 3D in vitro culture models. This is the first report demonstrating the comprehensive pro-angiogenic characterisation and the feasibility of using biobanked DPSCs for vascularised tissue engineering, highlighting their strong clinical applicability for future regenerative therapies.
Authors
- Francesco Torelli (ORCID: https://orcid.org/0009-0001-1887-0579)
- Shuntaro Yamada (ORCID: https://orcid.org/0000-0003-0282-5498)
- Kamal Noaman Mustafa (ORCID: https://orcid.org/0000-0002-2968-2856)
- Inge Fristad (ORCID: https://orcid.org/0000-0002-3054-6501)
- Ana Angelova Volponi (ORCID: https://orcid.org/0000-0002-5661-0807)
- Kateřina Holomková (ORCID: https://orcid.org/0000-0002-5133-4946)
- Pierfrancesco Pagella (ORCID: https://orcid.org/0000-0001-6912-0957)
- Hiroshi Egusa (ORCID: https://orcid.org/0000-0002-0200-8132)
- Niyaz Al‐Sharabi (ORCID: https://orcid.org/0000-0001-5526-5995)
- Masoumeh Jahani Kadousaraei (ORCID: https://orcid.org/0009-0009-6428-9804)
- Åshild Johansen (ORCID: https://orcid.org/0009-0008-6295-4957)
Institutions
- Linköping University (SE)
- King's College London (GB)
- Tohoku University (JP)
- Masaryk University (CZ)
- Czech Academy of Sciences, Institute of Animal Physiology and Genetics (CZ)
- University of Bergen (NO)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1111/iej.70036
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- European Commission
- Universitetet i Bergen
- Norges Forskningsråd
- Erasmus+