Towards Malaria Elimination: A Nationwide Case–Control Study to Assess Risk Factors for Severe Malaria‐Related Deaths in Brazil
This nationwide record-linkage study shows that malaria deaths remain concentrated in socially vulnerable groups: infants, older adults, and especially indigenous populations living in the Amazon. Delayed treatment is also a determinant for deaths, in both endemic and non-endemic regions, while active case detection markedly reduces the odds of death. To reach Brazil's zero-malaria-death target by 2030, it is needed to improve timely diagnosis and treatment, to enhance epidemiological information systems along with active surveillance amplification in remote communities. Finally, integrating national health-information systems allows real-time monitoring, and with coordinated action, eliminating malaria deaths remains achievable.
Authors
- Marcus Lacerda (ORCID: https://orcid.org/0000-0003-3374-9985)
- Amanda Amaral Abrahão (ORCID: https://orcid.org/0000-0002-7537-7561)
- CHRIS J. DRAKELEY (ORCID: https://orcid.org/0000-0003-4863-075X)
- Klauss Kleydmann Sabino Garcia (ORCID: https://orcid.org/0000-0003-2268-8742)
- Anderson Coutinho da Silva (ORCID: https://orcid.org/0009-0007-4960-6782)
- Walter Massa Ramalho (ORCID: https://orcid.org/0000-0001-5085-5670)
- Gabriel Zorello Laporta (ORCID: https://orcid.org/0000-0001-7412-9390)
- Seyi Soremekun (ORCID: https://orcid.org/0000-0002-5531-0220)
- Anielle de Pina Costa
- André M. Siqueira (ORCID: https://orcid.org/0000-0003-2208-0294)
Institutions
- Universidade de Brasília (BR)
- Universidade Federal Fluminense (BR)
- Fundação de Medicina Tropical (BR)
- London School of Hygiene & Tropical Medicine (GB)
- Brazilian Society of Tropical Medicine (BR)
- Faculdade de Medicina do ABC (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Tropical Medicine & International Health
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1111/tmi.70028
- Citations
- 2
- Primary Topic
- Global Maternal and Child Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Bill and Melinda Gates Foundation
- Universidade de Brasília
- London School of Hygiene and Tropical Medicine
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Ministério da Saúde