Identifying therapeutic targets for allergic asthma through atopic dermatitis–associated genetic mechanisms
We provide the first genomic evidence for a causal link between AD and AA. These findings highlight <i>JAK2</i> as a potential therapeutic target and hydroxyurea as a candidate for clinical validation, paving the way for future research into shared immunogenetic mechanisms in allergic diseases.
Authors
- Kei Hang Katie Chan (ORCID: https://orcid.org/0000-0001-9070-5394)
- Jundong Liu (ORCID: https://orcid.org/0000-0003-4423-4119)
- Yinshuang Pu
- Adam N. Bennett (ORCID: https://orcid.org/0000-0001-8307-327X)
Institutions
- City University of Hong Kong (HK)
- Brown University (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1016/j.jacig.2025.100568
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00