Swietenia mahagoni Leaves Ethanolic Extract: In vitro anti-Oxidant Activity, Active Compound Identification and in silico Prediction as AKT-1 and MDM2 Protein Inhibitor

The strong correlation between traditional practices and the pharmacological properties of these plants supports their continued use in treating various health conditions. This study evaluated and predicted the active compound in the ethanolic extract of Swietenia mahagoni leaves and their potency for inhibiting cancer cell growth. The analysis included measuring DPPH free radical inhibition, total phenolic and flavonoid content, drug-likeness evaluation, and molecular docking studies. Findings suggest that the ethanolic extract of S. mahagoni leaves ethanolic extract exhibits antioxidant properties due to its content of phenolic and flavonoid compounds such as Quercitrin, (+)-ar-Turmerone, and Hyperoside, which also meet Lipinski's criteria. Additionally, these compounds might act as inhibitors of MDM2 or AKT-1, potentially blocking MDM2 and AKT-1 and inducing apoptosis in cancer cells. Further research should be conducted in vitro to validate the activity of the studied compounds.