Downregulated of CTGF reveals mechanism, remodels immune microenvironment, modulates drug sensitivity in bladder cancer
This study elucidated the low expression of CTGF in BLCA. CTGF may promotes tumor progression by remodeling the immune microenvironment and extracellular matrix. Additionally, its expression is positively correlated with sensitivity to EGFR inhibitors and negatively correlated with resistance to PARP inhibitors.
Authors
- Lili Deng (ORCID: https://orcid.org/0000-0002-4871-4518)
- Guangming Tan (ORCID: https://orcid.org/0000-0002-6361-5948)
- Rong‐Quan He (ORCID: https://orcid.org/0000-0002-7752-2080)
- Hanjie Zhang (ORCID: https://orcid.org/0000-0002-0015-5614)
- Yiyu Dong (ORCID: https://orcid.org/0000-0002-5391-4936)
- Diyuan Qin
- Yi‐Wu Dang (ORCID: https://orcid.org/0000-0002-7793-1239)
- Gang Chen (ORCID: https://orcid.org/0000-0001-6067-6959)
- Juan He (ORCID: https://orcid.org/0000-0001-9245-869X)
- Zhen‐Bo Feng (ORCID: https://orcid.org/0000-0001-6361-4198)
- Shenghua Li (ORCID: https://orcid.org/0000-0001-9208-2119)
- Yiyang Chen (ORCID: https://orcid.org/0000-0003-0152-8563)
- Guoqiang Chen (ORCID: https://orcid.org/0000-0003-4936-2363)
- Kaiqiang Tang
- J. C. Ling
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi University of Science and Technology (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Future Science OA
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1080/20565623.2025.2560297
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00