Paracetamol Half-Life Declines over Time After an Acute Overdose
Our results suggest that the half-life of paracetamol decreases during acetylcysteine treatment. Health care professionals should consider repeated measurements of paracetamol concentrations and calculation of half-lives when using paracetamol half-life as a marker of hepatotoxicity, particularly when deciding whether to extend acetylcysteine treatment beyond the duration stated in the current guidelines.
Authors
- Daan J. Touw (ORCID: https://orcid.org/0000-0002-1429-4789)
- Marieke G. G. Sturkenboom (ORCID: https://orcid.org/0000-0002-3420-0591)
- Johannes A. Kroes (ORCID: https://orcid.org/0000-0002-9418-4861)
- Berdien Oortgiesen (ORCID: https://orcid.org/0000-0001-8401-9144)
- Jeroen Poortvliet
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Medisch Centrum Leeuwarden (NL)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1097/ftd.0000000000001395
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca