Psychosis and Catatonia in a Patient after Taking Baclofen: A Case Report

Baclofen is a centrally acting GABA-B receptor agonist commonly used to manage spasticity from conditions such as cerebral palsy, spinal cord injury, and multiple sclerosis. It is also employed off-label for alcohol dependence and other conditions like persistent hiccups. Baclofen’s mechanism of action involves reducing neuronal excitability by stimulating inhibitory signals and reducing excitatory neurotransmitter release. Although rare, overdose or dose escalation can lead to severe neurological effects, including delirium, seizures, and psychosis. We report a case of a 45-year-old man who developed catatonia and psychosis after high-dose baclofen use for dorsal pain.