Patient Subgroups and Predictors of Improvement in Chronic Neuropathic Pain: A Trajectory‐Based Analysis

This study highlights the value of trajectory analysis in identifying subgroups of patients with chronic neuropathic pain (NP) who exhibit different patterns of treatment response. Only a minority of patients-approximately 23% for both pain intensity and pain interference-demonstrated meaningful improvement. Lower baseline pain intensity and interference emerged as key predictors of better outcomes, while strong opioid use was associated with persistent severe pain. These findings underscore the importance of trajectory-based approaches for understanding the course of NP and for guiding more personalised and effective management in multidisciplinary care settings.