Design, synthesis, and cytotoxicity evaluation of 1,2,3-triazole-linked β-carboline–benzimidazole hybrids as tubulin polymerization inhibitors
A series of 1,2,3-triazole-linked β-carboline–benzimidazole hybrids were designed, synthesized and evaluated for their cytotoxic potential. Compounds 14d and 14o exhibited potent cytotoxicity against MCF-7 and tubulin polymerization inhibition.
Authors
- Mursalim Ali Khan
- Chandraiah Godugu (ORCID: https://orcid.org/0000-0001-5904-3134)
- Nagula Shankaraiah (ORCID: https://orcid.org/0000-0002-8733-9431)
- Anamika Sharma (ORCID: https://orcid.org/0000-0002-0054-9904)
- Preethi K. Raman
- Naveen Chand Rallabandi
Institutions
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
- National Institute of Pharmaceutical Education and Research (IN)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nj03098f
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00